Ovarian Stimulation to Collect Oocytes

Germeyer, Ariane; von Wolff, Michael (2020). Ovarian Stimulation to Collect Oocytes. In: von Wolff, Michael; Nawroth, Frank (eds.) Fertility Preservation in Oncological and Non-Oncological Diseases (pp. 169-178). Cham: Springer 10.1007/978-3-030-47568-0_19

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The chapter focuses on the established treatment options to preserve fertility using ovarian stimulation with its well-known rates of conception using cryopreserved oocytes/embryos. Due to the special character of ovarian stimulation in the context of fertility preservation, where endometrial characteristics can be ignored, new options of ovarian stimulation need to be considered. Besides the fact that ovarian hyperstimulation syndrome needs to be avoided, time is limited, and the number of oocytes retrieved for cryopreservation should be optimized. Therefore, this chapter describes unique stimulation protocols including random start of stimulation, adequate amounts of gonadotropins used, double stimulation, ovulation inhibition using progestins, as well as using an aromatase inhibitor to reduce the amount of estrogen production in cases of a hormone receptor-positive tumour. Finally, the optimal combination of fertility preservation techniques is described.

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