Pregnancy After Chemotherapy and Pelvic Radiotherapy

von Wolff, Michael (2020). Pregnancy After Chemotherapy and Pelvic Radiotherapy. In: von Wolff, Michael; Nawroth, Frank (eds.) Fertility Preservation in Oncological and Non-Oncological Diseases (pp. 269-271). Cham: Springer 10.1007/978-3-030-47568-0_30

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The effect of chemotherapy on a later pregnancy seems to be rather small. However, alkylating agents in childhood might have a negative effect on uterine function. The effect of radiotherapy depends strongly on the radiation intensity and the age at radiation exposure. Radiation during childhood seems to have a greater negative effect on the uterus than in adulthood. Radiotherapy to the adult uterus with whole-body radiation (12 Gy) is associated with an increased risk of abortion, premature birth and a low birth weight. If the uterus is irradiated with >25 Gy in childhood, pregnancy should not be recommended. If the uterus is irradiated with >45 Gy in adults, pregnancy should not be advised.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

von Wolff, Michael

Subjects:

600 Technology > 610 Medicine & health

ISBN:

978-3-030-47567-3

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

16 Mar 2021 17:37

Last Modified:

17 Mar 2021 09:00

Publisher DOI:

10.1007/978-3-030-47568-0_30

BORIS DOI:

10.48350/153987

URI:

https://boris.unibe.ch/id/eprint/153987

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