Chest pulse-wave velocity: a novel approach to assess arterial stiffness

Solà, Josep; Chételat, Olivier; Sartori, Claudio; Allemann, Yves; Rimoldi, Stefano F (2011). Chest pulse-wave velocity: a novel approach to assess arterial stiffness. IEEE transactions on biomedical engineering, 58(1), pp. 215-23. New York, N.Y.: Institute of Electrical and Electronics Engineers IEEE 10.1109/TBME.2010.2071385

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Pulse-wave velocity (PWV) is considered as the gold-standard method to assess arterial stiffness, an independent predictor of cardiovascular morbidity and mortality. Current available devices that measure PWV need to be operated by skilled medical staff, thus, reducing the potential use of PWV in the ambulatory setting. In this paper, we present a new technique allowing continuous, unsupervised measurements of pulse transit times (PTT) in central arteries by means of a chest sensor. This technique relies on measuring the propagation time of pressure pulses from their genesis in the left ventricle to their later arrival at the cutaneous vasculature on the sternum. Combined thoracic impedance cardiography and phonocardiography are used to detect the opening of the aortic valve, from which a pre-ejection period (PEP) value is estimated. Multichannel reflective photoplethysmography at the sternum is used to detect the distal pulse-arrival time (PAT). A PTT value is then calculated as PTT = PAT - PEP. After optimizing the parameters of the chest PTT calculation algorithm on a nine-subject cohort, a prospective validation study involving 31 normo- and hypertensive subjects was performed. 1/chest PTT correlated very well with the COMPLIOR carotid to femoral PWV (r = 0.88, p < 10 (-9)). Finally, an empirical method to map chest PTT values onto chest PWV values is explored.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Allemann, Yves, Rimoldi, Stefano
ISSN:	0018-9294
Publisher:	Institute of Electrical and Electronics Engineers IEEE
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:10
Last Modified:	05 Dec 2022 14:01
Publisher DOI:	10.1109/TBME.2010.2071385
PubMed ID:	20813631
Web of Science ID:	000285515500026
URI:	https://boris.unibe.ch/id/eprint/1540 (FactScience: 203315)