Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia

Jayet, Pierre-Yves; Rimoldi, Stefano F; Stuber, Thomas; Salmòn, Carlos Salinas; Hutter, Damian; Rexhaj, Emrush; Thalmann, Sébastien; Schwab, Marcos; Turini, Pierre; Sartori-Cucchia, Céline; Nicod, Pascal; Villena, Mercedes; Allemann, Yves; Scherrer, Urs; Sartori, Claudio (2010). Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation, 122(5), pp. 488-94. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.110.941203

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Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the diseased placenta. We speculated that these factors pass the placental barrier and leave a defect in the circulation of the offspring that predisposes to a pathological response later in life. The hypoxia associated with high-altitude exposure is expected to facilitate the detection of this problem.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Rimoldi, Stefano and Allemann, Yves

ISSN:

0009-7322

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1161/CIRCULATIONAHA.110.941203

PubMed ID:

20644018

Web of Science ID:

000280561100008

URI:

https://boris.unibe.ch/id/eprint/1541 (FactScience: 203316)

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