Mechanisms of nanoparticle-mediated photomechanical cell damage

Peeters, Sara; Kitz, Michael; Preisser, Stefan; Wetterwald, Antoinette; Rothen-Rutishauser, Barbara; Thalmann, George N; Brandenberger, Christina; Bailey, Arthur; Frenz, Martin (2012). Mechanisms of nanoparticle-mediated photomechanical cell damage. Biomedical optics express, 3(3), pp. 435-46. Washington, D.C.: Optical Society of America 10.1364/BOE.3.000435

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Laser-assisted killing of gold nanoparticle targeted macrophages was investigated. Using pressure transient detection, flash photography and transmission electron microscopy (TEM) imaging, we studied the mechanism of single cell damage by vapor bubble formation around gold nanospheres induced by nanosecond laser pulses. The influence of the number of irradiating laser pulses and of particle size and concentration on the threshold for acute cell damage was determined. While the single pulse damage threshold is independent of the particle size, the threshold decreases with increasing particle size when using trains of pulses. The dependence of the cell damage threshold on the nanoparticle concentration during incubation reveals that particle accumulation and distribution inside the cell plays a key role in tissue imaging or cell damaging.

Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Institute of Applied Physics 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
UniBE Contributor:	Peeters, Sara Elisa, Preisser, Stefan, Thalmann, George, Frenz, Martin
ISSN:	2156-7085
Publisher:	Optical Society of America
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:38
Last Modified:	05 Dec 2022 14:12
Publisher DOI:	10.1364/BOE.3.000435
PubMed ID:	22435092
Web of Science ID:	000302787000006
URI:	https://boris.unibe.ch/id/eprint/15435 (FactScience: 222780)