Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice.

Kou, Jiejian; Wang, Minghui; Shi, Junzhuo; Zhang, Haiyu; Pu, Xiaohui; Song, Shiyong; Yang, Cuiling; Yan, Yi; Döring, Yvonne; Xie, Xinmei; Pang, Xiaobin (2021). Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice. ACS Omega, 6(10), pp. 6654-6662. American Chemical Society 10.1021/acsomega.0c04810

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Apolipoprotein E4 (ApoE4) is the main genetic risk factor for Alzheimer's disease (AD), but the exact way in which it causes AD remains unclear. Curcumin is considered to have good therapeutic potential for AD, but its mechanism has not been clarified. This study aims to observe the effect of curcumin on ApoE4 transgenic mice and explore its possible molecular mechanism. Eight-month-old ApoE4 transgenic mice were intraperitoneally injected with curcumin for 3 weeks, and the Morris water maze test was used to evaluate the cognitive ability of the mice. Immunofluorescence staining, immunohistochemistry, western blotting, and enzyme-linked immunosorbent assay (ELISA) were used to examine the brain tissues of the mice. Curcumin reduced the high expression of ApoE4 and the excessive release of inflammatory factors in ApoE4 mice. In particular, the expression of marker proteins of endoplasmic reticulum (ER) stress was significantly increased in ApoE4 mice, while curcumin significantly reduced the increase in the expression of these proteins. Collectively, curcumin alleviates neuroinflammation in the brains of ApoE4 mice by inhibiting ER stress, thus improving the learning and cognitive ability of transgenic mice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Döring, Yvonne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2470-1343

Publisher:

American Chemical Society

Language:

English

Submitter:

Rebecca Scheidegger

Date Deposited:

28 Apr 2021 11:11

Last Modified:

05 May 2021 06:47

Publisher DOI:

10.1021/acsomega.0c04810

PubMed ID:

33748578

BORIS DOI:

10.48350/154675

URI:

https://boris.unibe.ch/id/eprint/154675

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