Rapid downregulation of innate immune cells, interleukin-12 and interleukin-23 in generalized pustular psoriasis with infliximab in combination with acitretin

Tang, M M; Spanou, Z; Tang, H; Schibler, F; Pelivani, N; Yawalkar, N (2012). Rapid downregulation of innate immune cells, interleukin-12 and interleukin-23 in generalized pustular psoriasis with infliximab in combination with acitretin. Dermatology, 225(4), pp. 338-43. Basel: Karger 10.1159/000346243

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Generalized pustular psoriasis (GPP) is a severe inflammatory disease characterized by recurrent eruptions of sterile pustules on erythematous skin. Although tumor necrosis factor (TNF) antagonists may lead to a rapid resolution of GPP, the mechanism of action of these agents remains to be investigated. Here, we sought to evaluate markers of immune response in the skin of a patient who experienced a rapid amelioration of GPP after treatment with infliximab and acitretin.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Spanou, Zoi and Pelivani, Nedzmidin

ISSN:

1018-8665

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

17 Mar 2015 21:31

Publisher DOI:

10.1159/000346243

PubMed ID:

23343611

Web of Science ID:

000315976300009

URI:

https://boris.unibe.ch/id/eprint/15493 (FactScience: 222847)

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