Hendaoui, Ismaïl; Lahmar, Ahlem; Campo, Luca; Mebarki, Sihem; Bichet, Sandrine; Hess, Daniel; Degen, Martin; Kchir, Nidhameddine; Charrada-Ben Farhat, Leila; Hefaiedh, Rania; Ruiz, Christian; Terracciano, Luigi M; Tucker, Richard P; Hendaoui, Lotfi; Chiquet-Ehrismann, Ruth (2021). Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers. Frontiers in immunology, 11, p. 630139. Frontiers Research Foundation 10.3389/fimmu.2020.630139
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DataSheet_1_Tenascin-W_Is_a_Novel_Stromal_Marker_in_Biliary_Tract_Cancers.pdf - Supplemental Material Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils in vitro. Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Orthodontic Research |
UniBE Contributor: |
Degen, Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Renate Imhof-Etter |
Date Deposited: |
26 Apr 2021 14:50 |
Last Modified: |
05 Dec 2022 15:50 |
Publisher DOI: |
10.3389/fimmu.2020.630139 |
PubMed ID: |
33692777 |
Uncontrolled Keywords: |
extracellular matrix gallbladder cancer tenascin-C tenascin-N tenascin-W tumor stroma |
BORIS DOI: |
10.48350/155256 |
URI: |
https://boris.unibe.ch/id/eprint/155256 |
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