Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers

Hendaoui, Ismaïl; Lahmar, Ahlem; Campo, Luca; Mebarki, Sihem; Bichet, Sandrine; Hess, Daniel; Degen, Martin; Kchir, Nidhameddine; Charrada-Ben Farhat, Leila; Hefaiedh, Rania; Ruiz, Christian; Terracciano, Luigi M; Tucker, Richard P; Hendaoui, Lotfi; Chiquet-Ehrismann, Ruth (2021). Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers. Frontiers in immunology, 11, p. 630139. Frontiers Research Foundation 10.3389/fimmu.2020.630139

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Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils in vitro. Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Orthodontic Research

UniBE Contributor:

Degen, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Renate Imhof-Etter

Date Deposited:

26 Apr 2021 14:50

Last Modified:

05 Dec 2022 15:50

Publisher DOI:

10.3389/fimmu.2020.630139

PubMed ID:

33692777

Uncontrolled Keywords:

extracellular matrix gallbladder cancer tenascin-C tenascin-N tenascin-W tumor stroma

BORIS DOI:

10.48350/155256

URI:

https://boris.unibe.ch/id/eprint/155256

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