Campylobacter jejuni from Canine and Bovine Cases of Campylobacteriosis Express High antimicrobial Resistance Rates against (Fluoro)quinolones and Tetracyclines

Moser, Sarah; Seth-Smith, Helena; Egli, Adrian; Kittl, Sonja; Overesch, Gudrun (2020). Campylobacter jejuni from Canine and Bovine Cases of Campylobacteriosis Express High antimicrobial Resistance Rates against (Fluoro)quinolones and Tetracyclines. Pathogens, 9(9) MDPI AG 10.3390/pathogens9090691

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Campylobacter (C.) spp. from poultry is the main source of foodborne human campylobacteriosis, but diseased pets and cattle shedding Campylobacter spp. may contribute sporadically as a source of human infection. As fluoroquinolones are one of the drugs of choice for the treatment of severe human campylobacteriosis, the resistance rates of C. jejuni and C. coli from poultry against antibiotics, including fluoroquinolones, are monitored within the European program on antimicrobial resistance (AMR) in livestock. However, much less is published on the AMR rates of C. jejuni and C. coli from pets and cattle. Therefore, C. jejuni and C. coli isolated from diseased animals were tested phenotypically for AMR, and associated AMR genes or mutations were identified by whole genome sequencing. High rates of resistance to (fluoro)quinolones (41%) and tetracyclines (61.1%) were found in C. jejuni (n = 29/66). (Fluoro)quinolone resistance was associated with the known point mutation in the quinolone resistance-determining region (QRDR) of gyrA, and tetracycline resistance was mostly caused by the tet(O) gene. These high rates of resistance, especially to critically important antibiotics in C. jejuni and C. coli, are worrisome not only in veterinary medicine. Efforts to preserve the effcacy of important antimicrobial treatment options in human and veterinary medicine have to be strengthened in the future.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Moser, Sarah; Kittl, Sonja and Overesch, Gudrun

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

2076-0817

Publisher:

MDPI AG

Language:

English

Submitter:

Gudrun Overesch

Date Deposited:

07 Apr 2021 16:14

Last Modified:

11 Apr 2021 03:08

Publisher DOI:

10.3390/pathogens9090691

PubMed ID:

32842457

BORIS DOI:

10.48350/155434

URI:

https://boris.unibe.ch/id/eprint/155434

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