Noninvasive Assessment of Schistosoma-Related Periportal Fibrosis.

Hashim, Ahmed; Berzigotti, Annalisa (2021). Noninvasive Assessment of Schistosoma-Related Periportal Fibrosis. (In Press). Journal of ultrasound in medicine Wiley 10.1002/jum.15623

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Schistosomiasis affects nearly 250 million individuals in the world. Hepatosplenic schistosomiasis (HSS) results in periportal fibrosis (PPF) and portal hypertension (pHTN). Ultrasound has been extensively used for the diagnosis of Schistosoma-related PPF and a number of staging methods have been validated for this purpose such as Strickland classification and Niamey protocol. Nevertheless, the application of noninvasive techniques, particularly elastography modalities, has not been well explored. In this review, we describe the various noninvasive diagnostic tools for assessment of Schistosoma-related PPF including US parameters, serum biomarkers, and US-based elastography techniques. While elastography techniques have demonstrated value in the evaluation of HSS, the evidence remains limited with most studies recruiting a small number of patients. Longitudinal studies with larger sample size are required in order to devise robust criteria to accurately assess the performance of noninvasive techniques in the prediction of both regression and progression of the degree of PPF and identify their cost-effectiveness in community screening.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Berzigotti, Annalisa

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0278-4297

Publisher:

Wiley

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

12 May 2021 14:46

Last Modified:

12 May 2021 14:46

Publisher DOI:

10.1002/jum.15623

PubMed ID:

33448437

Uncontrolled Keywords:

abdominal ultrasound elastography noninvasive assessment periportal fibrosis portal hypertension schistosomiasis

BORIS DOI:

10.48350/155526

URI:

https://boris.unibe.ch/id/eprint/155526

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