Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology.

Leroux, Cédric; Konstantinidou, Georgia (2021). Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology. Cancers, 13(4) MDPI AG 10.3390/cancers13040799

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Cytotoxic chemotherapy remains the only treatment option for most pancreatic ductal adenocarcinoma patients. Currently, the median overall survival of patients with advanced disease rarely exceeds 1 year. The complex network of pancreatic cancer composed of immune cells, endothelial cells, and cancer-associated fibroblasts confers intratumoral and intertumoral heterogeneity with distinct proliferative and metastatic propensity. This heterogeneity can explain why tumors do not behave uniformly and are able to escape therapy. The advance in technology of whole-genome sequencing has now provided the possibility of identifying every somatic mutation, copy-number change, and structural variant in a given cancer, giving rise to personalized targeted therapies. In this review, we provide an overview of the current and emerging treatment strategies in pancreatic cancer. By highlighting new paradigms in pancreatic ductal adenocarcinoma treatment, we hope to stimulate new thoughts for clinical trials aimed at improving patient outcomes.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Leroux, Cédric and Konstantinidou, Georgia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Celine Joray

Date Deposited:

06 Apr 2021 13:44

Last Modified:

07 Apr 2021 01:35

Publisher DOI:

10.3390/cancers13040799

PubMed ID:

33672917

Uncontrolled Keywords:

DNA repair autophagy epigenetic alterations immunotherapy key mutations pancreatic ductal adenocarcinoma therapies tumor microenvironment

BORIS DOI:

10.48350/155533

URI:

https://boris.unibe.ch/id/eprint/155533

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