Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells

Malliaras, Konstantinos; Li, Tao-Sheng; Luthringer, Daniel; Terrovitis, John; Cheng, Ke; Chakravarty, Tarun; Galang, Giselle; Zhang, Yiqiang; Schoenhoff, Florian; Van Eyk, Jennifer; Marbán, Linda; Marbán, Eduardo (2012). Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation, 125(1), pp. 100-12. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.111.042598

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Cardiosphere-derived cells (CDCs) are an attractive cell type for tissue regeneration, and autologous CDCs are being tested clinically. However, autologous therapy necessitates patient-specific tissue harvesting and cell processing, with delays to therapy and possible variations in cell potency. The use of allogeneic CDCs, if safe and effective, would obviate such limitations. We compared syngeneic and allogeneic CDC transplantation in rats from immunologically-mismatched inbred strains.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Schönhoff, Florian

ISSN:

0009-7322

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

17 Mar 2015 21:31

Publisher DOI:

10.1161/CIRCULATIONAHA.111.042598

PubMed ID:

22086878

Web of Science ID:

000299169100023

URI:

https://boris.unibe.ch/id/eprint/15555 (FactScience: 222931)

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