Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection.

Forrer, Anja; Schoenrath, Felix; Torzewski, Michael; Schmid, Jens; Franke, Urlich F W; Göbel, Nora; Aujesky, Drahomir; Matter, Christian M; Lüscher, Thomas F; Mach, Francois; Nanchen, David; Rodondi, Nicolas; Falk, Volkmar; von Eckardstein, Arnold; Gawinecka, Joanna (2021). Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection. Diagnostics, 11(4), p. 615. MDPI 10.3390/diagnostics11040615

[img]
Preview
Text
Forrer_DiagnosticsBasel_2021.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Acute aortic dissection (AAD) is a rare condition, but together with acute myocardial infarction (AMI) and pulmonary embolism (PE) it belongs to the most relevant and life-threatening causes of acute chest pain. Until now, there has been no specific blood test in the diagnostic workup of AAD. To identify clinically relevant biomarkers for AAD, we applied Proseek® Multiplex assays to plasma samples from patients with AAD, AMI, PE, thoracic aortic aneurysm (TAA), and non-cardiovascular chest pain (nonCVD). Subsequently, we validated top hits using conventional immunoassays and examined their expression in the aortic tissue. Interleukin 10 (IL-10) alone showed the best performance with a sensitivity of 55% and a specificity of 98% for AAD diagnosis. The combination of D-dimers, high-sensitive troponin T (hs-TnT), interleukin 6 (IL-6), and plasminogen activator inhibitor 1 (PAI1) correctly classified 75% of AAD cases, delivering a sensitivity of 83% and specificity of 95% for its diagnosis. Moreover, this model provided the correct classification of 77% of all analyzed cases. Our data suggest that IL-10 shows potential to be a rule-in biomarker for AAD. Moreover, the addition of PAI1 and IL-6 to hs-TnT and D-dimers may improve the discrimination of suspected AAD, AMI, and PE in patients presenting with acute chest pain.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Aujesky, Drahomir and Rodondi, Nicolas

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2075-4418

Publisher:

MDPI

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

08 Apr 2021 09:25

Last Modified:

08 Apr 2021 09:25

Publisher DOI:

10.3390/diagnostics11040615

PubMed ID:

33808169

Uncontrolled Keywords:

D-dimers IL-10 acute aortic dissection acute myocardial infarction biomarker pulmonary embolism

BORIS DOI:

10.48350/155661

URI:

https://boris.unibe.ch/id/eprint/155661

Actions (login required)

Edit item Edit item
Provide Feedback