Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery.

Boughton, Charlotte K; Daly, Aideen; Thabit, Hood; Hartnell, Sara; Herzig, David; Vogt, Andreas; Ruan, Yue; Wilinska, Malgorzata E; Evans, Mark L; Coll, Anthony P; Bally, Lia; Hovorka, Roman (2021). Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes, obesity & metabolism, 23(8), pp. 1978-1982. Wiley 10.1111/dom.14396

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OBJECTIVE

To characterise variability of exogenous insulin requirements during fully closed-loop insulin delivery in hospitalised patients with type 2 diabetes (T2D) or new-onset hyperglycaemia, and to determine patient-related characteristics associated with higher variability of insulin requirements.

RESEARCH DESIGN AND METHODS

We retrospectively analysed data from two fully closed-loop inpatient studies involving adults with T2D or new-onset hyperglycaemia requiring insulin therapy. The coefficient of variation quantified day-to-day variability of exogenous insulin requirements during up to 15 days using fully automated closed-loop insulin delivery.

RESULTS

Data from 535 days in 67 participants were analysed. The coefficient of variation of day-to-day exogenous insulin requirements was 30±16% and was higher between nights than between any daytime period (56±29% overnight [2300-0459] compared with 41±21% in the morning [0500-1059], 39±15% in the afternoon [1100-1659] and 45±19% during the evening [1700-2259]; all p<0.01).

CONCLUSIONS

There is high day-to-day variability of exogenous insulin requirements in inpatients, particularly overnight, and diabetes management approaches should account for this variability. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Herzig, David; Vogt, Andreas and Bally, Lia Claudia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1463-1326

Publisher:

Wiley

Language:

English

Submitter:

Laura Goetschi

Date Deposited:

06 May 2021 14:50

Last Modified:

19 Jul 2021 16:25

Publisher DOI:

10.1111/dom.14396

PubMed ID:

33822461

BORIS DOI:

10.48350/155680

URI:

https://boris.unibe.ch/id/eprint/155680

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