Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients.

Nenoff, Lena; Matter, Michael; Amaya, Enrique Javier; Josipovic, Mirjana; Knopf, Antje-Christin; John Lomax, Antony; Persson, Gitte F; Ribeiro, Cássia O; Visser, Sabine; Walser, Marc; Weber, Damien Charles; Zhang, Ye; Albertini, Francesca (2021). Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients. Radiotherapy and oncology, 159, pp. 136-143. Elsevier 10.1016/j.radonc.2021.03.021

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PURPOSE

A major burden of introducing an online daily adaptive proton therapy (DAPT) workflow is the time and resources needed to correct the daily propagated contours. In this study, we evaluated the dosimetric impact of neglecting the online correction of the propagated contours in a DAPT workflow.

MATERIAL AND METHODS

For five NSCLC patients with nine repeated deep-inspiration breath-hold CTs, proton therapy plans were optimised on the planning CT to deliver 60Gy-RBE in 30 fractions. All repeated CTs were registered with six different clinically used deformable image registration (DIR) algorithms to the corresponding planning CT. Structures were propagated rigidly and with each DIR algorithm and reference structures were contoured on each repeated CT. DAPT plans were optimised with the uncorrected, propagated structures (propagated DAPT doses) and on the reference structures (ideal DAPT doses), non-adapted doses were recalculated on all repeated CTs.

RESULTS

Due to anatomical changes occurring during the therapy, the clinical target volume (CTV) coverage of the non-adapted doses reduces on average by 9.7% (V95) compared to an ideal DAPT doses. For the propagated DAPT doses, the CTV coverage was always restored (average differences in the CTV V95 <1% compared to the ideal DAPT doses). Hotspots were always reduced with any DAPT approach.

CONCLUSION

For the patients presented here, a benefit of online DAPT was shown, even if the daily optimisation is based on propagated structures with some residual uncertainties. However, a careful (offline) structure review is necessary and corrections can be included in an offline adaption.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Weber, Damien Charles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-8140

Publisher:

Elsevier

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

11 May 2021 15:18

Last Modified:

11 May 2021 15:26

Publisher DOI:

10.1016/j.radonc.2021.03.021

PubMed ID:

33771576

BORIS DOI:

10.48350/155693

URI:

https://boris.unibe.ch/id/eprint/155693

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