Localized and Locally Advanced Prostate Cancer: Treatment Options.

Achard, Vérane; Panje, Cédric Michael; Engeler, Daniel; Zilli, Thomas; Putora, Paul Martin (2021). Localized and Locally Advanced Prostate Cancer: Treatment Options. Oncology - international journal of cancer research and treatment, 99(7), pp. 413-421. Karger 10.1159/000513258

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BACKGROUND

There are many treatment options for localized and locally advanced prostate cancer with radiotherapy and surgery representing the main local therapeutic strategies.

SUMMARY

Depending on the risk of disease recurrence, we can stratify patients into low-, intermediate- and high-risk groups, which will guide patients' treatment. For low-risk patients, active surveillance is an option. Brachytherapy is also an option for low- and intermediate-risk patients and can be used as a boost following external beam radiotherapy for high-risk patients. For intermediate- and high-risk patients, radical prostatectomy and radiotherapy should be considered. Moreover, in addition to radiotherapy, concomitant androgen deprivation therapy may be needed. Finally, after radical prostatectomy and depending on pathological, biological and clinical factors, radiotherapy ± androgen deprivation therapy can be proposed as an adjuvant or salvage treatment. Key Messages: With radiotherapy and surgery being well-established treatment options for localized prostate cancer patients with equally good overall survival rates, priority must be given to patients' choice concerning the logistics and the toxicity profile of each option.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Putora, Paul Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0030-2414

Publisher:

Karger

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

11 May 2021 14:57

Last Modified:

24 Jun 2021 01:33

Publisher DOI:

10.1159/000513258

PubMed ID:

33784675

Uncontrolled Keywords:

Patients’ quality of life Prostate cancer Radical prostatectomy Radiotherapy

URI:

https://boris.unibe.ch/id/eprint/155696

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