Antibacterial effect of silver diamine fluoride and potassium iodide against E. faecalis, A. naeslundii and P. micra

Briseño Marroquin, Benjamin; Ismael, Yasmine; Callaway, Angelika; Tennert, Christian; Wolf, Thomas Gerhard (2021). Antibacterial effect of silver diamine fluoride and potassium iodide against E. faecalis, A. naeslundii and P. micra. BMC Oral Health, 21(1), pp. 1-7. BioMed Central 10.1186/s12903‐021‐01531‐1

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Background: The aim of this study was to determine in vitro the bactericidal potential of 38% silver diamine fluoride (SDF) alone, potassium iodide (PI) alone, and the two in combination (SDF + PI) against three bacterial species com‐ monly found in root canal samples (Enterococcus faecalis, Actinomyces naeslundii and Parvimonas micra).
Methods: The potential bactericidal rates for SDF, PI and SDF + PI against E. faecalis, A. naeslundii and P. micra were calculated as reduction of bacteria colony forming units.
Results: The bactericidal potential of SDF was at 99.97–100% against E. faecalis and 100% against A. naeslundii and P. micra. SDF + PI showed a 100% bactericidal effect against P. micra, 99.89–99.98% against E. faecalis and 99.98–100% against A. naeslundii. The bactericidal effect of PI was 99.51–99.98% against E. faecalis, 99.27–99.95% against A. naes- lundii and 99.93–100% against P. micra. The differences between controls and bacteria exposed to the antibacterial agents were statistically significant (p < 0.05).
Conclusions: SDF had an effective bactericidal effect against the examined bacteria. However, the limitations of this in vitro study do not allow a recommendation of the employment of these solutions as root canal irrigants. Additional investigations are necessary to assess their endodontic clinical applicability.

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