Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring.

Steiner, Leonie; Homan, Stephanie; Everts, Regula; Federspiel, Andrea; Kamal, Sandeep; Rodriguez, Juan Antonio Delgado; Kornfeld, Salome; Slavova, Nedelina; Wiest, Roland; Kaelin-Lang, Alain; Steinlin, Maja; Grunt, Sebastian (2021). Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring. Scientific reports, 11(1), p. 5490. Springer Nature 10.1038/s41598-021-84671-2

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To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in patients with hemiparesis compared with typically developing peers. We included 18 patients (n = 9 with hemiparesis, n = 9 with good motor outcome) with pediatric AIS in the chronic phase (≥ 2 years after diagnosis, diagnosed > 16 years) and 18 peers matched by age and gender. Participants underwent a standardized motor assessment, single-pulse transcranial magnetic stimulation to determine the type of corticospinal tract wiring, and resting-state functional magnetic resonance imaging to examine motor network connectivity. Corticospinal tract wiring was contralateral in all participants. Patients with hemiparesis had lower interhemispheric connectivity strength compared with patients with good clinical outcome and peers. Patients with good clinical outcome had higher intrahemispheric connectivity strength compared with peers. Further, higher intrahemispheric connectivity was related to better motor outcome in patients. Our findings suggest that better motor outcome after pediatric AIS is related to higher motor network connectivity strength. Thus, resting-state functional connectivity might be predictive for motor recovery after pediatric AIS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Steiner, Leonie Serena; Everts, Regula; Federspiel, Andrea; Kamal, Sandeep; Kornfeld, Salome; Slavova, Nedelina Bozhidarova; Wiest, Roland; Steinlin, Maja and Grunt, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

27 Apr 2021 16:58

Last Modified:

02 May 2021 03:06

Publisher DOI:

10.1038/s41598-021-84671-2

PubMed ID:

33750854

BORIS DOI:

10.48350/155899

URI:

https://boris.unibe.ch/id/eprint/155899

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