Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits.

Wanderer, Stefan; Grüter, Basil Erwin; Strange, Fabio; Boillat, Gwendoline; Sivanrupan, Sivani; Rey, Jeannine; von Gunten, Michael; Remonda, Luca; Widmer, Hans Rudolf; Casoni, Daniela; Andereggen, Lukas; Fandino, Javier; Marbacher, Serge (2022). Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits. Journal of neurointerventional surgery, 14(2), pp. 189-195. BMJ Publishing Group 10.1136/neurintsurg-2020-017261

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Aneurysm wall degeneration is linked to growth and rupture. To address the effect of aspirin (ASA) on aneurysm formation under various wall conditions, this issue was analyzed in a novel rabbit bifurcation model.


Bifurcation aneurysms created in 45 New Zealand White rabbits were randomized to vital (n=15), decellularized (n=13), or elastase-degraded (n=17) wall groups; each group was assigned to a study arm with or without ASA. At follow-up 28 days later, aneurysms were evaluated for patency, growth, and wall inflammation at macroscopic and histological levels.


36 rabbits survived to follow-up at the end of the trial. None of the aneurysms had ruptured. Patency was visualized in all aneurysms by intraoperative fluorescence angiography and confirmed in 33 (92%) of 36 aneurysms by MRI/MRA. Aneurysm size was significantly increased in the vital (without ASA) and elastase-degraded (with and without ASA) groups. Aneurysm thrombosis was considered complete in three (50%) of six decellularized aneurysms without ASA by MRI/MRA. Locoregional inflammation of the aneurysm complex was significantly reduced in histological analysis among all groups treated with ASA.


ASA intake prevented inflammation of both the periadventitial tissue and aneurysm wall, irrespective of initial wall condition. Although ASA prevented significant growth in aneurysms with vital walls, this preventive effect did not have an important role in elastase-degraded pouches. In possible translation to the clinical situation, ASA might exert a potential preventive effect during early phases of aneurysm formation in patients with healthy vessels but not in those with highly degenerative aneurysm walls.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Widmer, Hans Rudolf; Casoni, Daniela and Andereggen, Lukas


600 Technology > 610 Medicine & health




BMJ Publishing Group




Nicole Söll

Date Deposited:

07 Jun 2021 15:20

Last Modified:

21 Jan 2022 00:11

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

aneurysm artery blood flow inflammation magnetic resonance angiography




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