Diffuse Leptomeningeal Oligodendrogliomatosis in a Cow.

Kauer, Ronja V; Bagatella, Stefano; Oevermann, Anna (2020). Diffuse Leptomeningeal Oligodendrogliomatosis in a Cow. Veterinary pathology, 57(2), pp. 253-257. 10.1177/0300985819887534

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A 4.5-year-old cow showing neurological signs consistent with predictors of bovine spongiform encephalopathy (BSE) was investigated as a potential BSE-suspect case and proved to be negative. Macroscopic analysis revealed a tan neoplastic mass growing along the leptomeninges of the caudal brain and extending into the third (III) ventricle without significantly involving the neuroparenchyma. Pathological features (uniform round hyperchromatic neoplastic cells embedded in abundant myxoid matrix, microcysts, microvascular proliferation) and diffuse Olig2 expression were most consistent with diffuse high-grade leptomeningeal oligodendrogliomatosis. In line with former reports of extensive leptomeningeal involvement in bovine oligodendroglioma, this report suggests that bovine oligodendroglial tumors have a strong propensity to grow within the leptomeningeal space. In addition, it indicates that Olig2 is a useful marker to confirm glial lineage in formalin-fixed, paraffin-embedded bovine tissue.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Oevermann, Anna

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

1544-2217

Language:

English

Submitter:

Anna Oevermann

Date Deposited:

26 Apr 2021 13:11

Last Modified:

05 Dec 2022 15:50

Publisher DOI:

10.1177/0300985819887534

PubMed ID:

31842702

Uncontrolled Keywords:

BSE Olig2 bovine cattle diffuse leptomeningeal glioneuronal tumor disseminated oligodendroglioma-like neoplasm leptomeningeal growth neuropathology oligodendroglioma

BORIS DOI:

10.48350/155977

URI:

https://boris.unibe.ch/id/eprint/155977

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