Large-Scale Comparison of Toxin and Antitoxins in Listeria monocytogenes.

Agüero, José Antonio; Akarsu, Hatice; Aguilar-Bultet, Lisandra; Oevermann, Anna; Falquet, Laurent (2020). Large-Scale Comparison of Toxin and Antitoxins in Listeria monocytogenes. Toxins, 12(1) MDPI 10.3390/toxins12010029

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Toxin-antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in Listeria monocytogenes (Lm), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania database, we focused on the known and new putative TASs in 352 Listeria monocytogenes genomes and identified the putative core gene TASs (cgTASs) with the Pasteur BIGSdb-Lm database and, by complementarity, the putative accessory gene TAS (acTASs). We combined the cgTASs with those of an additional 227 L. monocytogenes isolates from our previous studies containing metadata information. We discovered that the differences in 14 cgTAS alleles are sufficient to separate the four main lineages of Listeria monocytogenes. Analyzing these differences in more details, we uncovered potentially co-evolving residues in some pairs of proteins in cgTASs, probably essential for protein-protein interactions within the TAS complex.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Akarsu Egger, Hatice and Oevermann, Anna

Subjects:

600 Technology > 630 Agriculture

ISSN:

2072-6651

Publisher:

MDPI

Language:

English

Submitter:

Anna Oevermann

Date Deposited:

26 Apr 2021 17:13

Last Modified:

26 Apr 2021 17:20

Publisher DOI:

10.3390/toxins12010029

PubMed ID:

31906535

Uncontrolled Keywords:

Listeria monocytogenes co-evolution toxin–antitoxin systems

BORIS DOI:

10.48350/155978

URI:

https://boris.unibe.ch/id/eprint/155978

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