Biurrun Manresa, José A; Schliessbach, Jürg; Vuilleumier, Pascal Henri; Müller, Monika; Musshoff, Frank; Stamer, Ulrike; Stüber, Frank; Arendt-Nielsen, Lars; Curatolo, Michele (2021). Anti-Nociceptive Effects of Oxytocin Receptor Modulation in Healthy Volunteers - a Randomized, Double-Blinded, Placebo-Controlled Study. European journal of pain, 25(8), pp. 1723-1738. Wiley 10.1002/ejp.1781
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Anti-nociceptive_effects_of_oxytocin_Stamer_St_ber_EurJPain_2021.pdf - Accepted Version Available under License Publisher holds Copyright. Download (7MB) | Preview |
BACKGROUND
There is increasing evidence for oxytocin as a neurotransmitter in spinal nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal horn, where they activate GABA-ergic inhibitory interneurons. The present study tested whether the long-acting oxytocin-analogue carbetocin has anti-nociceptive effects in multi-modal experimental pain in humans.
METHODS
Twenty-five male volunteers received carbetocin 100 mcg and placebo (0.9% NaCl) on two different sessions in a randomized, double-blinded, cross-over design. Multi-modal quantitative sensory testing (QST) including a model of capsaicin-induced hyperalgesia and allodynia were performed at baseline and at 10, 60 and 120 minutes after drug administration. QST data were analyzed using mixed linear and logistic regression models. Carbetocin plasma concentrations and oxytocin receptor genotypes were quantified and assessed in an exploratory fashion.
RESULTS
An anti-nociceptive effect of carbetocin was observed on intramuscular electrical temporal summation (estimated difference: 1.26 mA, 95%-CI 1.01 to 1.56 mA, p = 0.04) and single-stimulus electrical pain thresholds (estimated difference: 1.21 mA, 95%-CI 1.0 to 1.47 mA, p = 0.05). Furthermore, the area of capsaicin-induced allodynia was reduced after carbetocin compared to placebo (estimated difference: -6.5 cm2 , 95%-CI -9.8 to -3.2 cm2 , p < 0.001).
CONCLUSIONS
This study provides evidence of an anti-nociceptive effect of carbetocin on experimental pain in humans.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > University Psychiatric Services |
UniBE Contributor: |
Schliessbach, Jürg, Vuilleumier, Pascal Henri, Müller, Monika, Stamer, Ulrike, Stüber, Frank, Curatolo, Michele |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1090-3801 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
07 Jun 2021 16:37 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1002/ejp.1781 |
PubMed ID: |
33884702 |
Uncontrolled Keywords: |
Oxytocin / analogs & derivates hyperalgesia interneurons spinal cord dorsal horn |
BORIS DOI: |
10.48350/156044 |
URI: |
https://boris.unibe.ch/id/eprint/156044 |
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