Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study.

Lupatsch, Judith E.; Kreis, Christian; Konstantinoudis, Garyfallos; Ansari, Marc; Kuehni, Claudia E.; Spycher, Ben D. (2021). Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study. CCC. Cancer causes & control, 32(7), pp. 713-723. Springer 10.1007/s10552-021-01423-3

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PURPOSE

Initial genetic alterations in the development of childhood leukemia occur in utero or before conception; both genetic and environmental factors are suspected to play a role. We aimed to investigate the associations between childhood leukemia and perinatal characteristics including birth order, birth interval to older siblings, parental age, birth weight, and multiple birth.

METHODS

We identified cases diagnosed between 1981 and 2015 and born in Switzerland between 1969 and 2015 from the Swiss Childhood Cancer Registry and randomly sampled five controls per case from national birth records matched on date of birth, sex, and municipality of residence at birth. We used conditional logistic regression to investigate associations between perinatal characteristics and leukemia at ages 0-15 and 0-4 years, and the subtypes acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

RESULTS

The study included 1,403 cases of leukemia. We observed increased risks associated with high birth weight (adjusted OR 1.37, 95% CI 1.12-1.69) and multiple birth (1.89, 1.24-2.86). These associations were similar for ALL and stronger for leukemia at ages 0-4 years. For AML, we observed an increased risk for higher birth order (3.08, 0.43-22.03 for fourth or later born children). We found no associations with other perinatal characteristics.

CONCLUSION

This register-based case-control study adds to the existing evidence of a positive association between high birth weight and risk of childhood leukemia. Furthermore, it suggests children from multiple births are at an increased risk of leukemia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Lupatsch, Judith Eva; Kreis, Christian; Konstantinoudis, Garyfallos; Kühni, Claudia and Spycher, Ben

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0957-5243

Publisher:

Springer

Funders:

[189] Swiss Cancer Research = Krebsforschung Schweiz ; [193] Swiss Cancer League = Krebsliga Schweiz ; [4] Swiss National Science Foundation

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

28 Apr 2021 11:52

Last Modified:

09 Jun 2021 01:34

Publisher DOI:

10.1007/s10552-021-01423-3

PubMed ID:

33877514

Additional Information:

Judith E. Lupatsch and Christian Kreis contributed equally to
this work. Open Access funding provided by Universität Bern.

Uncontrolled Keywords:

Birth weight Epidemiology Maternal age Parity Paternal age Twins

BORIS DOI:

10.48350/156077

URI:

https://boris.unibe.ch/id/eprint/156077

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