Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma.

Lese, Ioana; Tsai, Catherine; Matter, Martin; Wüthrich, Tsering; Scheer, Helene Sophie; Taddeo, Adriano; Constantinescu, Mihai Adrian; Herrmann, Inge Katrin; Olariu, Radu (2021). Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma. ACS biomaterials science & engineering, 7(6), pp. 2676-2686. American Chemical Society 10.1021/acsbiomaterials.1c00283

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Seroma formation is a well-recognized postoperative complication for many plastic and general surgical procedures. Although various tissue adhesives and substances have been used in an effort to treat seroma formation, no therapies have been established clinically. Recently, the nano-bridging phenomenon has been introduced as a promising approach to achieve tissue adhesion and strong closure of deep skin wounds in rats. The present study seeks to assess the potential of nano-bridging beyond skin wounds in a rat model of seroma. Seromas were induced in 20 Lewis rats through bilateral axillary lymphadenectomy, excision of the latissimus dorsi and cutaneous maximus muscles, and disruption of dermal lymphatics. On postoperative day (POD) 7, the seroma was aspirated on both sides. A bioactive nanoparticle (NP) suspension based on zinc-doped strontium-substituted bioglass/ceria nanoparticles (NP group) or fibrin glue (fibrin group) was injected into the right seroma cavity, while the left side was left untreated. On POD 14, the NP group showed complete remission (no seromas at all), while the fibrin group recorded a reduction of only 63% in the seroma fluid volume. The NPs exerted local anti-inflammatory and neo-angiogenic effects, without any detectable systemic changes. Moreover, the ceria levels recorded in the organs did not surpass the background level, indicating that the nanoparticles stayed at the site of application. This study is a promising first example demonstrating the ability of inorganic nanoparticle formulations to reduce seroma formation in a rat model, without any detectable systemic adverse effects. These results emphasize the potential of nanotechnological solutions in the therapeutic management of seroma in the clinical setting.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery

UniBE Contributor:

Lese, Ioana; Scheer, Helene Sophie; Constantinescu, Mihai Adrian and Olariu, Radu

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

2373-9878

Publisher:

American Chemical Society

Language:

English

Submitter:

Veronika Picha

Date Deposited:

06 May 2021 08:31

Last Modified:

16 Jun 2021 01:33

Publisher DOI:

10.1021/acsbiomaterials.1c00283

PubMed ID:

33890779

Uncontrolled Keywords:

animal model mixed metal oxide nanoparticles seroma

BORIS DOI:

10.48350/156190

URI:

https://boris.unibe.ch/id/eprint/156190

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