Basophils Orchestrating Eosinophils' Chemotaxis and Function in Allergic Inflammation.

Iype, Joseena; Fux, Michaela (2021). Basophils Orchestrating Eosinophils' Chemotaxis and Function in Allergic Inflammation. Cells, 10(4), p. 895. MDPI 10.3390/cells10040895

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Eosinophils are well known to contribute significantly to Th2 immunity, such as allergic inflammations. Although basophils have often not been considered in the pathogenicity of allergic dermatitis and asthma, their role in Th2 immunity has become apparent in recent years. Eosinophils and basophils are present at sites of allergic inflammations. It is therefore reasonable to speculate that these two types of granulocytes interact in vivo. In various experimental allergy models, basophils and eosinophils appear to be closely linked by directly or indirectly influencing each other since they are responsive to similar cytokines and chemokines. Indeed, basophils are shown to be the gatekeepers that are capable of regulating eosinophil entry into inflammatory tissue sites through activation-induced interactions with endothelium. However, the direct evidence that eosinophils and basophils interact is still rarely described. Nevertheless, new findings on the regulation and function of eosinophils and basophils biology reported in the last 25 years have shed some light on their potential interaction. This review will focus on the current knowledge that basophils may regulate the biology of eosinophil in atopic dermatitis and allergic asthma.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Iype, Joseena Mariam and Fux, Michaela

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2073-4409

Publisher:

MDPI

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

07 May 2021 14:51

Last Modified:

07 May 2021 15:33

Publisher DOI:

10.3390/cells10040895

PubMed ID:

33919759

Uncontrolled Keywords:

allergic asthma allergic inflammation atopic dermatitis basophils chemotaxis eosinophil infiltration eosinophil-basophil interaction eosinophils

BORIS DOI:

10.48350/156227

URI:

https://boris.unibe.ch/id/eprint/156227

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