Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile

Eleftheriadis, Theodoros; Antoniadi, Georgia; Liakopoulos, Vassilios; Pissas, Georgios; Arampatzis, Spyridon; Sparopoulou, Theodora; Galaktidou, Grammati; Stefanidis, Ioannis (2012). Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile. Therapeutic apheresis and dialysis, 16(4), pp. 355-60. Carlton South (Aus.): Blackwell Publishing 10.1111/j.1744-9987.2012.01080.x

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Perilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. Thirty-six HD patients and 28 healthy volunteers were enrolled into the study. Ten HD patients suffered from coronary heart disease (CHD). Perilipin-1, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), body mass index, albumin, geriatric nutritional risk index, normalized protein catabolic rate, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured. Perilipin-1 did not differ between HD patients and healthy volunteers. IL-6 and TNF-α were higher in HD patients. The evaluated nutritional markers and the markers of inflammation did not differ between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels. Regarding the lipid profile, only HDL-C differed between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels, and it was higher in the first subgroup. Perilipin-1 was significantly higher in HD patients without CHD. Perilipin-1 is detectable in the serum of HD patients and it is associated with increased HDL-C and decreased incidence of CHD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Arampatzis, Spyridon

ISSN:

1744-9979

Publisher:

Blackwell Publishing

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

17 Mar 2015 21:31

Publisher DOI:

10.1111/j.1744-9987.2012.01080.x

PubMed ID:

22817124

Web of Science ID:

000306687300009

URI:

https://boris.unibe.ch/id/eprint/15629 (FactScience: 223033)

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