Tischer, Christina; Karvonen, Anne M; Kirjavainen, Pirkka V; Flexeder, Claudia; Roponen, Marjut; Hyvärinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha (2021). Early age exposure to moisture and mould is related to FeNO at the age of 6 years. Pediatric allergy and immunology, 32(6), pp. 1226-1237. Wiley-Blackwell 10.1111/pai.13526
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BACKGROUND
Exposure to indoor moisture damage and visible mold has been found to be associated with asthma and respiratory symptoms in several questionnaire-based studies by self-report. We aimed to define the prospective association between the early life exposure to residential moisture damage or mold and fractional exhaled nitric oxide (FeNO) and lung function parameters as objective markers for airway inflammation and asthma in 6-year-old children.
METHODS
Home inspections were performed in children's homes when infants were on average 5 months old. At age 6 years, data on FeNO (n = 322) as well as lung function (n = 216) measurements were collected. Logistic regression and generalized additive models were used for statistical analyses.
RESULTS
Early age major moisture damage and moisture damage or mold in the child's main living areas were significantly associated with increased FeNO levels (>75th percentile) at the age of 6 years (adjusted odds ratios, 95% confidence intervals, aOR (95% CI): 3.10 (1.35-7.07) and 3.16 (1.43-6.98), respectively. Effects were more pronounced in those who did not change residential address throughout the study period. For lung function, major structural damage within the whole home was associated with reduced FEV1 and FVC, but not with FEV1/FVC. No association with lung function was observed with early moisture damage or mold in the child's main living areas.
CONCLUSION
These results underline the importance of prevention and remediation efforts of moisture and mold-damaged buildings in order to avoid harmful effects within the vulnerable phase of the infants and children's immunologic development.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie) 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology |
UniBE Contributor: |
Fuchs, Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0905-6157 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
14 May 2021 11:36 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1111/pai.13526 |
PubMed ID: |
33894090 |
Uncontrolled Keywords: |
asthma cohort study exhaled NO lung function moisture damage |
BORIS DOI: |
10.48350/156352 |
URI: |
https://boris.unibe.ch/id/eprint/156352 |
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