Detampel, Pascal; Beck, Mareike; Krähenbühl, Stephan; Huwyler, Jörg (2012). Drug interaction potential of resveratrol. Drug metabolism reviews, 44(3), pp. 253-65. New York, N.Y.: Informa Healthcare 10.3109/03602532.2012.700715
Full text not available from this repository. (Request a copy)Resveratrol is a naturally occurring polyphenol that is often used as a food supplement. Many positive health effects, including cardio protection, tumor suppression, and immune modulation, are associated with the intake of resveratrol. Resveratrol is well tolerated in healthy subjects without any comedication. However, supplemental doses of resveratrol in the range of 1 g/day or above by far exceed the natural intake through food. Whether resveratrol-drug interactions can be harmful in patients taking additional medications remains unknown. Recent in vivo studies and clinical trials indicate a possible drug-drug interaction potential using high-dosage formulations. In this review, the known in vitro and in vivo effects of resveratrol on various cytochrome P450 (CYP) isoenzymes are summarized. They are discussed in relation to clinically relevant plasma concentrations in humans. We conclude that resveratrol may lead to interactions with various CYPs, especially when taken in high doses. Aside from systemic CYP inhibition, intestinal interactions must also be considered. They can potentially lead to reduced first-pass metabolism, resulting in higher systemic exposure to certain coadministrated CYP substrates. Therefore, patients who ingest high doses of this food supplement combined with additional medications may be at risk of experiencing clinically relevant drug-drug interactions.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Krähenbühl-Melcher, Stephan |
ISSN: |
0360-2532 |
Publisher: |
Informa Healthcare |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:39 |
Last Modified: |
02 Mar 2023 23:21 |
Publisher DOI: |
10.3109/03602532.2012.700715 |
PubMed ID: |
22788578 |
Web of Science ID: |
000306423300003 |
URI: |
https://boris.unibe.ch/id/eprint/15645 (FactScience: 223055) |
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