Commissioning of a clinical pencil beam scanning proton therapy unit for ultra-high dose rates (FLASH).

Nesteruk, Konrad P; Togno, Michele; Grossmann, Martin; Lomax, Anthony J; Weber, Damien C; Schippers, Jacobus M; Safai, Sairos; Meer, David; Psoroulas, Serena (2021). Commissioning of a clinical pencil beam scanning proton therapy unit for ultra-high dose rates (FLASH). Medical physics, 48(7), pp. 4017-4026. Wiley 10.1002/mp.14933

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PURPOSE

The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultra-high dose rates.

METHODS

PSI Gantry 1 treated patients until December 2018. We optimized the beamline parameters to transport the 250 MeV beam extracted from the PSI COMET accelerator to the treatment room, maximizing the transmission of beam intensity to the sample. We characterized a dose monitor on the gantry to ensure good control of the dose, delivered in spot-scanning mode. We characterized the beam for different dose rates and field sizes for transmission irradiations. We explored scanning possibilities in order to enable conformal irradiations or transmission irradiations of large targets (with transverse scanning).

RESULTS

We achieved a transmission of 86 % from the cyclotron to the treatment room. We reached a peak dose rate of 9000 Gy/s at 3 mm water equivalent depth, along the central axis of a single pencil beam. Field sizes of up to 5x5 mm2 were achieved for single spot FLASH irradiations. Fast transverse scanning allowed to cover a field of 16x1.2 cm2 . With the use of a nozzle-mounted range shifter, we are able to span depths in water ranging from 19.6 to 37.9 cm. Various dose levels were delivered with precision within less than 1 %.

CONCLUSIONS

We have realized a proton FLASH irradiation setup able to investigate continuously a wide dose rate spectrum, from 1 to 9000 Gy/s in single spot irradiation as well as in the pencil beam scanning mode. As such, we have developed a versatile test bench for FLASH research.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Weber, Damien Charles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2473-4209

Publisher:

Wiley

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

16 Jun 2021 14:23

Last Modified:

29 Jul 2021 01:33

Publisher DOI:

10.1002/mp.14933

PubMed ID:

33963576

Uncontrolled Keywords:

FLASH gantry pencil beam scanning proton therapy ultra-high dose rates

BORIS DOI:

10.48350/156514

URI:

https://boris.unibe.ch/id/eprint/156514

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