Improving 1-year mortality prediction in ACS patients using machine learning.

Weichwald, Sebastian; Candreva, Alessandro; Burkholz, Rebekka; Klingenberg, Roland; Räber, Lorenz; Heg, Dik; Manka, Robert; Gencer, Baris; Mach, François; Nanchen, David; Rodondi, Nicolas; Windecker, Stephan; Laaksonen, Reijo; Hazen, Stanley L; von Eckardstein, Arnold; Ruschitzka, Frank; Lüscher, Thomas F; Buhmann, Joachim M; Matter, Christian M (2021). Improving 1-year mortality prediction in ACS patients using machine learning. European Heart Journal: Acute Cardiovascular Care, 10(8), pp. 855-865. Sage 10.1093/ehjacc/zuab030

Text Weichwald_EurHeartJAcuteCardiovascCare_2021_epub.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (970kB) | Request a copy

BACKGROUND

The Global Registry of Acute Coronary Events (GRACE) score is an established clinical risk stratification tool for patients with acute coronary syndromes (ACS). We developed and internally validated a model for 1-year all-cause mortality prediction in ACS patients.

METHODS

Between 2009 and 2012, 2'168 ACS patients were enrolled into the Swiss SPUM-ACS Cohort. Biomarkers were determined in 1'892 patients and follow-up was achieved in 95.8% of patients. 1-year all-cause mortality was 4.3% (n = 80). In our analysis we consider all linear models using combinations of 8 out of 56 variables to predict 1-year all-cause mortality and to derive a variable ranking.

RESULTS

1.3% of 1'420'494'075 models outperformed the GRACE 2.0 Score. The SPUM-ACS Score includes age, plasma glucose, NT-proBNP, left ventricular ejection fraction (LVEF), Killip class, history of peripheral artery disease (PAD), malignancy, and cardio-pulmonary resuscitation. For predicting 1-year mortality after ACS, the SPUM-ACS Score outperformed the GRACE 2.0 Score which achieves a 5-fold cross-validated AUC of 0.81 (95% CI 0.78-0.84). Ranking individual features according to their importance across all multivariate models revealed age, trimethylamine N-oxide, creatinine, history of PAD or malignancy, LVEF, and haemoglobin as the most relevant variables for predicting 1-year mortality.

CONCLUSIONS

The variable ranking and the selection for the SPUM-ACS Score highlight the relevance of age, markers of heart failure, and comorbidities for prediction of all-cause death. Before application, this score needs to be externally validated and refined in larger cohorts.

CLINICAL TRIAL REGISTRATION

NCT01000701.

Interest & Impact

Downloads

4 since deposited on 27 May 2021
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item