The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer.

Siegwart, Valerie; Steiner, Leonie; Pastore-Wapp, Manuela; Benzing, Valentin; Spitzhüttl, Janine; Schmidt, Mirko; Kiefer, Claus; Slavova, Nedelina; Grotzer, Michael; Roebers, Claudia; Steinlin, Maja; Leibundgut, Kurt; Everts, Regula (2021). The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer. Developmental neuropsychology, 46(3), pp. 249-264. Taylor & Francis 10.1080/87565641.2021.1922410

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Childhood cancer and its treatment puts survivors at risk of low working memory capacity. Working memory represents a core cognitive function, which is crucial in daily life and academic tasks. The aim of this functional MRI (fMRI) study was to examine the working memory network of survivors of childhood cancer without central nervous system (CNS) involvement and its relation to cognitive performance. Thirty survivors (aged 7-16 years, ≥ 1 year after cancer treatment) and 30 healthy controls performed a visuospatial working memory task during MRI, including a low- and a high-demand condition. Working memory performance was assessed using standardized tests outside the scanner. When cognitive demands increased, survivors performed worse than controls and showed evidence for slightly atypical working memory-related activation. The survivor group exhibited hyperactivation in the right-hemispheric superior parietal lobe (SPL) in the high- compared to the low-demand working memory condition, while maintaining their performance levels. Hyperactivation in the right SPL coincided with poorer working memory performance outside the scanner in survivors. Even in survivors of childhood cancer without CNS involvement, we find neural markers pointing toward late effects in the cerebral working memory network.AbbreviationsfMRI: Functional magnetic resonance imaging; CNS: Central nervous system; MNI: Montreal Neurological Institute; SES: Socioeconomic status; SPL: Superior parietal lobe.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Sport Science (ISPW)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics
07 Faculty of Human Sciences > Institute of Psychology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Siegwart, Valerie; Steiner, Leonie Serena; Pastore-Wapp, Manuela; Benzing, Valentin Johannes; Spitzhüttl, Janine Sophie; Schmidt, Mirko; Kiefer, Claus; Slavova, Nedelina Bozhidarova; Roebers, Claudia; Steinlin, Maja; Leibundgut, Kurt and Everts, Regula

Subjects:

700 Arts > 790 Sports, games & entertainment
600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology

ISSN:

1532-6942

Publisher:

Taylor & Francis

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

04 Jun 2021 16:37

Last Modified:

04 Jun 2021 16:37

Publisher DOI:

10.1080/87565641.2021.1922410

PubMed ID:

33969767

BORIS DOI:

10.48350/156579

URI:

https://boris.unibe.ch/id/eprint/156579

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