Introgression of ASIP and TYRP1 Alleles Explains Coat Color Variation in Valais Goats.

Henkel, Jan; Dubacher, Alexandra; Bangerter, Erika; Herren, Ursula; Ammann, Philippe; Drögemüller, Cord; Flury, Christine; Leeb, Tosso (2021). Introgression of ASIP and TYRP1 Alleles Explains Coat Color Variation in Valais Goats. (In Press). Journal of heredity Oxford University Press 10.1093/jhered/esab024

[img] Text
esab024__epub.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.
© The American Genetic Association. 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Download (1MB) | Request a copy
[img] Text
Manuscript_Henkel_accepted_version.pdf - Accepted Version
Restricted to registered users only until 30 May 2022.
Available under License Publisher holds Copyright.

Download (5MB) | Request a copy

The Valais Blackneck goat is a Swiss goat breed with a characteristic coat color phenotype. Before the revision of the breed standard in 1938, 4 different color varieties of Valais goats were known. Besides Blackneck animals resembling the modern breed standard, the brown and white Copperneck goat, the white Capra Sempione, and the greyish Grüenochte comprised the historic Valais goats. The brown pigmentation of Copperneck goats had previously been traced back to an introgression of a mutant TYRP1 allele from Toggenburg goats. In the present study, we identified additional introgression events of distinct ASIP alleles causing the remaining 2 rare coat color patterns within the Valais Blackneck goat breed. We identified the introgression of the AWt allele from Appenzell or Saanen goats in white Capra Sempione goats. Similarly, introgression of the Apc allele from Peacock goats resulted in the greyish Grüenochte phenotype. These results demonstrate past hybridization events between breeds that are separated today. A perfect genotype-phenotype association in 393 Valais goats supported the causality of the genotyped variants for the different coat color phenotypes. Our study gives insights into the introgression of functionally relevant copy number variant (CNV) alleles controlling pigmentation between goat breeds with strikingly different coat color patterns.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Henkel, Jan Wolfgang; Drögemüller, Cord and Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

0022-1503

Publisher:

Oxford University Press

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

07 Jun 2021 09:05

Last Modified:

07 Jun 2021 09:05

Publisher DOI:

10.1093/jhered/esab024

PubMed ID:

34050662

Uncontrolled Keywords:

Capra hircus agouti copy number variant gene flow pattern

BORIS DOI:

10.48350/156592

URI:

https://boris.unibe.ch/id/eprint/156592

Actions (login required)

Edit item Edit item
Provide Feedback