Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands

Schwickert, Kevin; Andrzejewski, Michal; Grabowsky, Simon; Schirmeister, Tanja (2021). Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands. The Journal of organic chemistry, 86(9), pp. 6169-6183. American Chemical Society 10.1021/acs.joc.0c02993

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Potential (trifluoromethyl)diazirine-basedTRPML1 ion channel ligands were designed and synthesized,and their structures were determined by single-crystal X-raydiffraction analysis. Photoactivation studies via19F NMR spec-troscopy and HPLC-MS analysis revealed distinct kineticalcharacteristics in selected solvents and favorable photochemicalproperties in an aqueous buffer. These photoactivatable TRPMLactivators represent useful and valuable tools for TRPMLphotoaffinity labeling combined with mass spectrometry

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Andrzejewski, Michal and Grabowsky, Simon

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1520-6904

Publisher:

American Chemical Society

Language:

English

Submitter:

Simon Grabowsky

Date Deposited:

03 Jun 2021 16:53

Last Modified:

03 Jun 2021 16:53

Publisher DOI:

10.1021/acs.joc.0c02993

BORIS DOI:

10.48350/156625

URI:

https://boris.unibe.ch/id/eprint/156625

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