The DEPTQ+ Experiment: Leveling the DEPT Signal Intensities and Clean Spectral Editing for Determining CHn Multiplicities

Bigler, Peter; Melendez, Camilo; Furrer, Julien (2021). The DEPTQ+ Experiment: Leveling the DEPT Signal Intensities and Clean Spectral Editing for Determining CHn Multiplicities. Molecules, 26(12), p. 3490. Molecular Diversity Preservation International MDPI 10.3390/molecules26123490

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We propose a new 13C DEPTQ+ NMR experiment, based on the improved DEPTQ experiment, which is designed to unequivocally identify all carbon multiplicities (Cq, CH, CH2, and CH3) in two experiments. Compared to this improved DEPTQ experiment, the DEPTQ+ is shorter and the different evolution delays are designed as spin echoes, which can be tuned to different 1JCH values; this is especially valuable when a large range of 1JCH coupling constants is to be expected. These modifications allow (i) a mutual leveling of the DEPT signal intensities, (ii) a reduction in J cross‐talk in the Cq/CH spectrum, and (iii) more consistent and cleaner CH2/CH3 edited spectra. The new DEPTQ+ is expected to be attractive for fast 13C analysis of small‐to medium sized molecules, especially in high‐throughput laboratories. With concentrated samples and/or by exploiting the high sensitivity of cryogenically cooled 13C NMR probeheads, the efficacy of such investigations may be improved, as it is possible to unequivocally identify all carbon multiplicities, with only one scan, for each of the two independent DEPTQ+ experiments and without loss of quality.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)
08 Faculty of Science > Other Institutions > Emeriti, Faculty of Science

UniBE Contributor:

Bigler, Peter; Melendez Becerra, Camilo Andres and Furrer, Julien

Subjects:

500 Science > 540 Chemistry

ISSN:

1420-3049

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Julien Henri Lucien Furrer

Date Deposited:

23 Jun 2021 18:47

Last Modified:

27 Jun 2021 03:07

Publisher DOI:

10.3390/molecules26123490

BORIS DOI:

10.48350/156788

URI:

https://boris.unibe.ch/id/eprint/156788

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