Shaping the slow waves of sleep: A systematic and integrative review of sleep slow wave modulation in humans using non-invasive brain stimulation

Fehér, Kristoffer D.; Wunderlin, Marina; Maier, Jonathan G.; Hertenstein, Elisabeth; Schneider, Carlotta L.; Mikutta, Christian; Züst, Marc A.; Klöppel, Stefan; Nissen, Christoph (2021). Shaping the slow waves of sleep: A systematic and integrative review of sleep slow wave modulation in humans using non-invasive brain stimulation. Sleep medicine reviews, 58, p. 101438. Elsevier 10.1016/j.smrv.2021.101438

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The experimental study of electroencephalographic slow wave sleep (SWS) stretches over more than half a century and has corroborated its importance for basic physiological processes, such as brain plasticity, metabolism and immune system functioning. Alterations of SWS in aging or pathological conditions suggest that modulating SWS might constitute a window for clinically relevant interventions. This work provides a systematic and integrative review of SWS modulation through non-invasive brain stimulation in humans. A literature search using PubMed, conducted in May 2020, identified 3220 studies, of which 82 fulfilled inclusion criteria. Three approaches have been adopted to modulate the macro- and microstructure of SWS, namely auditory, transcranial electrical and transcranial magnetic stimulation. Our current knowledge about the modulatory mechanisms, the space of stimulation parameters and the physiological and behavioral effects are reported and evaluated. The integration of findings suggests that sleep slow wave modulation bears the potential to promote our understanding of the functions of SWS and to develop new treatments for conditions of disrupted SWS.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Fehér, Daniel Kristoffer; Wunderlin, Marina; Maier, Jonathan Gabriel; Hertenstein, Elisabeth; Schneider, Carlotta Louisa; Mikutta, Christian Alexander; Züst, Marc; Klöppel, Stefan and Nissen, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1087-0792

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Klink

Date Deposited:

22 Jun 2021 09:58

Last Modified:

05 Aug 2021 01:33

Publisher DOI:

10.1016/j.smrv.2021.101438

PubMed ID:

33582581

BORIS DOI:

10.48350/156798

URI:

https://boris.unibe.ch/id/eprint/156798

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