Rate of treatment success and associated factors in the program for drug susceptible tuberculosis in the Forest Region, Republic of Guinea, 2010-2017: a real-world retrospective observational cohort study.

Schoenbaechler, Valérie; Guilavogui, Yakpazouo; Onivogui, Sosso; Hébélamou, Jean; Mugglin, Catrina; Furrer, Hansjakob; Henzen, Corina; Bavogui, Esther Kolou; Kolié, Cécé; Zoumanigui, Pévé; Béavogui, Ismaël; Leuenberger, David; Staehelin, Cornelia (2021). Rate of treatment success and associated factors in the program for drug susceptible tuberculosis in the Forest Region, Republic of Guinea, 2010-2017: a real-world retrospective observational cohort study. International journal of infectious diseases, 110, pp. 6-14. Elsevier 10.1016/j.ijid.2021.06.014

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OBJECTIVES

To analyze the treatment success rate (TSR = sum of cured or treatment completed) in the tuberculosis (TB) program for drug susceptible TB (DS-TB) of the "Centre Hospitalier Régional Spécialisé" in Macenta, Forest Region, Republic of Guinea.

METHODS

This cohort study included patients starting treatment for DS-TB between 2010 and 2017. Data collection was part of the documentation for the national TB program. Descriptive analysis was applied to determine TSR in various patient groups. Further, we performed logistic regression to determine factors influencing TSR, in new and relapse cases versus all other previously treated cases. A subgroup analysis for only microbiologically confirmed pulmonary TB was added.

RESULTS

We included 3,969 patients. TSR increased from 68.3% in 2010 to 80.8% in 2017 (p < 0.001). Mortality (11.2%) occurred mainly in early treatment months, while loss to follow-up (5.9%) increased towards later treatment months. Risk factors for low TSR were advanced age, positive HIV status, long travel distances (>100 km) to the clinic and late drug refill.

CONCLUSION

TSR in the Forest Region of Guinea remains below the WHO goal of 90%. Reaching this target remains a challenge in rural areas with high early mortality and increased risk of loss to follow-up.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Mugglin, Catrina Andrea; Furrer, Hansjakob and Staehelin, Cornelia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1201-9712

Publisher:

Elsevier

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

28 Jun 2021 17:10

Last Modified:

28 Sep 2021 01:32

Publisher DOI:

10.1016/j.ijid.2021.06.014

PubMed ID:

34118429

Uncontrolled Keywords:

Drug susceptible tuberculosis End TB Strategy Republic of Guinea TB-HIV co-infection sub-Sahara Africa treatment success rate

BORIS DOI:

10.48350/156895

URI:

https://boris.unibe.ch/id/eprint/156895

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