A Living Cell Repository of the Cranio-/Orofacial Region to Advance Research and Promote Personalized Medicine

Parisi, Ludovica; Knapp, Patrick O.; Girousi, Eleftheria; Rihs, Silvia; La Scala, Giorgio C.; Schnyder, Isabelle; Stähli, Alexandra; Sculean, Anton; Bosshardt, Dieter; Katsaros, Christos; Degen, Martin (2021). A Living Cell Repository of the Cranio-/Orofacial Region to Advance Research and Promote Personalized Medicine. Frontiers in cell and developmental biology, 9 Frontiers 10.3389/fcell.2021.682944

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The prevalence of congenital anomalies in newborns is estimated to be as high as 6%, many of which involving the cranio-/orofacial region. Such malformations, including several syndromes, are usually identified prenatally, at birth, or rarely later in life. The lack of clinically relevant human cell models of these often very rare conditions, the societal pressure to avoid the use of animal models and the fact that the biological mechanisms between rodents and human are not necessarily identical, makes studying cranio-/orofacial anomalies challenging. To overcome these limitations, we are developing a living cell repository of healthy and diseased cells derived from the cranio-/orofacial region. Ultimately, we aim to make patient-derived cells, which retain the molecular and genetic characteristics of the original anomaly or disease in vitro, available for the scientific community. We report our efforts in establishing a human living cell bank derived from the cranio-/orofacial region of otherwise discarded tissue samples, detail our strategy, processes and quality checks. Such specific cell models have a great potential for discovery and translational research and might lead to a better understanding and management of craniofacial anomalies for the benefit of all affected individuals.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Orthodontic Research

UniBE Contributor:

Parisi, Ludovica; Girousi, Eleftheria; Rihs, Silvia; Schnyder, Isabelle; Stähli, Alexandra Beatrice; Sculean, Anton; Bosshardt, Dieter; Katsaros, Christos and Degen, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2296-634X

Publisher:

Frontiers

Language:

English

Submitter:

Renate Imhof-Etter

Date Deposited:

28 Jun 2021 09:48

Last Modified:

28 Jun 2021 09:48

Publisher DOI:

10.3389/fcell.2021.682944

BORIS DOI:

10.48350/156915

URI:

https://boris.unibe.ch/id/eprint/156915

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