Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome.

Puledda, Francesca; O'Daly, Owen; Schankin, Christoph; Ffytche, Dominic; Williams, Steven Cr; Goadsby, Peter J (2021). Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome. Human brain mapping, 42(7), pp. 2032-2044. Wiley-Blackwell 10.1002/hbm.25343

[img]
Preview
Text
Puledda__2021__Disrupted_connectivity_within_networks.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (4MB) | Preview

Here we investigate brain functional connectivity in patients with visual snow syndrome (VSS). Our main objective was to understand more about the underlying pathophysiology of this neurological syndrome. Twenty-four patients with VSS and an equal number of gender and age-matched healthy volunteers attended MRI sessions in which whole-brain maps of functional connectivity were acquired under two conditions: at rest while watching a blank screen and during a visual paradigm consisting of a visual-snow like stimulus. Eight unilateral seed regions were selected a priori based on previous observations and hypotheses; four seeds were placed in key anatomical areas of the visual pathways and the remaining were derived from a pre-existing functional analysis. The between-group analysis showed that patients with VSS had hyper and hypoconnectivity between key visual areas and the rest of the brain, both in the resting state and during a visual stimulation, compared with controls. We found altered connectivity internally within the visual network; between the thalamus/basal ganglia and the lingual gyrus; between the visual motion network and both the default mode and attentional networks. Further, patients with VSS presented decreased connectivity during external sensory input within the salience network, and between V5 and precuneus. Our results suggest that VSS is characterised by a widespread disturbance in the functional connectivity of several brain systems. This dysfunction involves the pre-cortical and cortical visual pathways, the visual motion network, the attentional networks and finally the salience network; further, it represents evidence of ongoing alterations both at rest and during visual stimulus processing.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schankin, Christoph Josef

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1065-9471

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

30 Jun 2021 12:19

Last Modified:

30 Jun 2021 12:19

Publisher DOI:

10.1002/hbm.25343

PubMed ID:

33448525

Uncontrolled Keywords:

functional connectivity magnetic resonance imaging migraine photophobia prolonged visual disturbance salience network visual motion network visual snow syndrome

BORIS DOI:

10.48350/157124

URI:

https://boris.unibe.ch/id/eprint/157124

Actions (login required)

Edit item Edit item
Provide Feedback