Eosinophils in skin diseases.

Radonjic-Hoesli, Susanne; Brüggen, Marie-Charlotte; Feldmeyer, Laurence; Simon, Hans-Uwe; Simon, Dagmar (2021). Eosinophils in skin diseases. Seminars in immunopathology, 43(3), pp. 393-409. Springer 10.1007/s00281-021-00868-7

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Eosinophil infiltration is a common finding in a broad spectrum of skin diseases, despite the fact that the skin is devoid of eosinophils under physiologic conditions. Although cutaneous eosinophilia is reactive, cytokine-mediated in most cases, diseases with an intrinsic mutation-mediated clonal expansion of eosinophils can also manifest on the skin. As eosinophils are involved in host defense, regulate immune responses, generate pruritus, induce remodeling and fibrosis, and can cause tissue damage, they have the capacity to actively contribute to the pathogenesis of diseases. Recent research provided deeper insights in the mechanisms, e.g., bacterial and viral clearance, blister formation, recruitment of cytotoxic T cells, and generation of pruritus, by which eosinophils might come into action. This review aims at providing an overview on the clinical presentations of eosinophil-associated dermatoses and the current understanding of their pathogenic role in these diseases. Further, we discuss the effects of therapies targeting eosinophils.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Radonjic, Susanne Irene; Feldmeyer, Laurence; Simon, Hans-Uwe and Simon, Dagmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1863-2300

Publisher:

Springer

Language:

English

Submitter:

Celine Joray

Date Deposited:

30 Jun 2021 17:41

Last Modified:

02 Jul 2021 01:34

Publisher DOI:

10.1007/s00281-021-00868-7

PubMed ID:

34097126

Uncontrolled Keywords:

Eosinophil Granule proteins Host defense Immunoregulation Tissue damage

BORIS DOI:

10.48350/157248

URI:

https://boris.unibe.ch/id/eprint/157248

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