Korda, Athanasia; Zee, David S; Wyss, Thomas; Zamaro, Ewa; Caversaccio, Marco D; Wagner, Franca; Kalla, Roger; Mantokoudis, Georgios (2021). Impaired fixation suppression of horizontal vestibular nystagmus during smooth pursuit: pathophysiology and clinical implications. European journal of neurology, 28(8), pp. 2614-2621. Wiley 10.1111/ene.14909
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BACKGROUND AND PURPOSE
A peripheral spontaneous nystagmus (SN) is typically enhanced or revealed by removing fixation. Conversely, failure of fixation suppression of SN is usually a sign of a central disorder. Based on Luebke and Robinson (Vision Res 1988, vol. 28 (8), pp. 941-946), who suggested that the normal fixation mechanism is disengaged during pursuit, it is hypothesized that vertical tracking in the light would bring out or enhance a horizontal SN.
METHODS
Eighteen patients with acute vestibular neuritis were studied. Eye movements were recorded using video-oculography at straight-ahead gaze with and without visual fixation, and during smooth pursuit. The slow-phase velocity and the fixation suppression indices of nystagmus (relative to SN in darkness) were compared in each condition.
RESULTS
During vertical tracking, the slow-phase velocity of horizontal SN with eyes near straight-ahead gaze was significantly higher (median 2.7°/s) than under static visual fixation (median 1.2°/s). Likewise, the fixation index was significantly higher (worse suppression) during pursuit (median 48%) than during fixation (median 26%). A release of SN was also suggested during horizontal pursuit, if one assumes superposition of SN on a normal and symmetrical pursuit capability.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Korda, Athanasia, Wyss, Thomas Werner, Zamaro, Ewa, Caversaccio, Marco, Wagner, Franca, Kalla, Roger, Mantokoudis, Georgios |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-1331 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Martin Zbinden |
Date Deposited: |
06 Jul 2021 12:22 |
Last Modified: |
02 Mar 2023 23:35 |
Publisher DOI: |
10.1111/ene.14909 |
PubMed ID: |
33983645 |
Uncontrolled Keywords: |
fixation suppression nystagmus pursuit vestibular |
BORIS DOI: |
10.48350/157291 |
URI: |
https://boris.unibe.ch/id/eprint/157291 |
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