Blondiaux, Eva; Heydrich, Lukas Emmanuel Josef Marc; Blanke, Olaf (2021). Common and distinct brain networks of autoscopic phenomena. NeuroImage: Clinical, 30, p. 102612. Elsevier 10.1016/j.nicl.2021.102612
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Blondiaux__2021__Common_and_distinct_brain_networks.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (2MB) | Preview |
OBJECTIVE
Autoscopic phenomena (AP) are illusory own body reduplications characterized by the visual perception of a second own body in extrapersonal space, and include three main forms: autoscopic hallucination (AH), heautoscopy (HAS) and out-of-body-experience (OBE). Past research showed that lesions were heterogeneously distributed and affected many different brain regions within and across patients, while small case series suggested that AP lesions converge in temporo-parietal and parieto-occipital cortex. As only few studies investigated each form of AP separately, it remains unknown whether the three AP are characterized by common and distinct brain mechanisms.
METHODS
Here, we applied lesion network analysis in 26 neurological AP patients and determined their common and distinct functional connectivity patterns.
RESULTS
We report that all localize to a single common brain network at the bilateral temporo-parietal junction, further associated with specific patterns of functional connectivity, defining each type of AP. OBE resulted from a brain network connected to bilateral angular gyrus, right precuneus, and right inferior frontal gyrus, differing from AH with a brain network connected to bilateral precuneus, inferior temporal gyrus, and cerebellum. HAS resulted from a brain network connected to left inferior frontal gyrus, left insula and left parahippocampus.
CONCLUSION
The present data identify the temporo-parietal junction as the common core region for AP and show that each form of AP recruits additional specific networks, associated with different sensorimotor and self-related sub-networks.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Heydrich, Lukas Emmanuel Josef Marc |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2213-1582 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
12 Jul 2021 16:08 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1016/j.nicl.2021.102612 |
PubMed ID: |
33714069 |
Uncontrolled Keywords: |
Bodily self-consciousness Lesion network mapping Multisensory processing Temporo-parietal junction |
BORIS DOI: |
10.48350/157366 |
URI: |
https://boris.unibe.ch/id/eprint/157366 |
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