De Schoenmacker, Iara; Berry, Carson; Blouin, Jean-Sébastien; Rosner, Jan; Hubli, Michèle; Jutzeler, Catherine R; Kramer, John L K (2021). An intensity matched comparison of laser- and contact heat evoked potentials. Scientific reports, 11(1), p. 6861. Springer Nature 10.1038/s41598-021-85819-w
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Previous studies comparing laser (LEPs) and contact heat evoked potentials (CHEPs) consistently reported higher amplitudes following laser compared to contact heat stimulation. However, none of the studies matched the perceived pain intensity, questioning if the observed difference in amplitude is due to biophysical differences between the two methods or a mismatch in stimulation intensity. The aims of the current study were twofold: (1) to directly compare the brain potentials induced by intensity matched laser and contact heat stimulation and (2) investigate how capsaicin-induced secondary hyperalgesia modulates LEPs and CHEPs. Twenty-one healthy subjects were recruited and measured at four experimental sessions: (1) CHEPs + sham, (2) LEPs + sham, (3) CHEPs + capsaicin, and (4) LEPs + capsaicin. Baseline (sham) LEPs latency was significantly shorter and amplitude significantly larger compared to CHEPs, even when matched for perceived pain. Neither CHEPs nor LEPs was sensitive enough to detect secondary hyperalgesia. These differences provide evidence that a faster heating rate results in an earlier and more synchronized LEPs than CHEPs. To our knowledge, this was the first study to match perceived intensity of contact heat and laser stimulations, revealing distinct advantages associated with the acquisition of LEPs.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Rosner, Jan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
06 Jul 2021 17:22 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1038/s41598-021-85819-w |
PubMed ID: |
33767259 |
BORIS DOI: |
10.48350/157373 |
URI: |
https://boris.unibe.ch/id/eprint/157373 |
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