De Marchis, Gian Marco; Sposato, Luciano A; Kühne, Michael; Dittrich, Tolga D; Bonati, Leo H; Fischer, Urs; Chaturvedi, Seemant (2021). New Avenues for Optimal Treatment of Atrial Fibrillation and Stroke Prevention. Stroke, 52(4), pp. 1490-1499. American Heart Association 10.1161/STROKEAHA.120.032060
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One in 3 individuals free of atrial fibrillation (AF) at index age 55 years is estimated to develop AF later in life. AF increases not only the risk of ischemic stroke but also of dementia, even in stroke-free patients. In this review, we address recent advances in the heart-brain interaction with focus on AF. Issues discussed are (1) the timing of direct oral anticoagulants start following an ischemic stroke; (2) the comparison of direct oral anticoagulants versus vitamin K antagonists in early secondary stroke prevention; (3) harms of bridging with heparin before direct oral anticoagulants; (4) importance of appropriate direct oral anticoagulants dosing; (5) screening for AF in high-risk populations, including the role of wearables; (6) left atrial appendage occlusion as an alternative to oral anticoagulation; (7) the role of early rhythm-control therapy; (8) effect of lifestyle interventions on AF; (9) AF as a risk factor for dementia. An interdisciplinary approach seems appropriate to address the complex challenges posed by AF.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Fischer, Urs Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1524-4628 |
Publisher: |
American Heart Association |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
13 Jul 2021 15:17 |
Last Modified: |
02 Mar 2023 23:35 |
Publisher DOI: |
10.1161/STROKEAHA.120.032060 |
PubMed ID: |
33626906 |
Uncontrolled Keywords: |
anticoagulant atrial appendage atrial fibrillation dementia hemorrhage |
BORIS DOI: |
10.48350/157476 |
URI: |
https://boris.unibe.ch/id/eprint/157476 |