Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa.

Wiest, C; Tinkhauser, G; Pogosyan, A; He, S; Baig, F; Morgante, F; Mostofi, A; Pereira, E A; Tan, H; Brown, P; Torrecillos, F (2021). Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa. Neurobiology of disease, 152, p. 105287. Elsevier 10.1016/j.nbd.2021.105287

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Finely-tuned gamma (FTG) oscillations can be recorded from cortex or the subthalamic nucleus (STN) in patients with Parkinson's disease (PD) on dopaminergic medication, and have been associated with dyskinesias. When recorded during deep brain stimulation (DBS) on medication the FTG is entrained to half the stimulation frequency. We investigated whether these characteristics are shared off medication by recording local field potentials (LFP) from the STN from externalised DBS leads in 14 PD patients after overnight withdrawal of medication. FTG was induced de-novo by DBS in the absence of dyskinesias in a third of our cohort. The FTG could outlast stimulation or arise only after DBS ceased. FTG frequencies decreased during and across consecutive DBS blocks, but did not shift with changing stimulation frequency off medication. Together with the sustained after-effects this argues against simple entrainment by DBS in the off medication state. We also found significant coherence between STN-LFP and electroencephalogram (EEG) signals at FTG frequencies. We conclude that FTG is a network phenomenon that behaves differently in the off medication state, when it is neither associated with dyskinesias nor susceptible to entrainment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Tinkhauser, Gerd

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0969-9961

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

12 Jul 2021 17:58

Last Modified:

05 Dec 2022 15:52

Publisher DOI:

10.1016/j.nbd.2021.105287

PubMed ID:

33549721

Uncontrolled Keywords:

Adaptive deep brain stimulation Feedback markers Finely-tuned gamma Local field potentials Parkinson's disease

BORIS DOI:

10.48350/157477

URI:

https://boris.unibe.ch/id/eprint/157477

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