Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network.

Bernasconi, Fosco; Blondiaux, Eva; Potheegadoo, Jevita; Stripeikyte, Giedre; Pagonabarraga, Javier; Bejr-Kasem, Helena; Bassolino, Michela; Akselrod, Michel; Martinez-Horta, Saul; Sampedro, Frederic; Hara, Masayuki; Horvath, Judit; Franza, Matteo; Konik, Stéphanie; Bereau, Matthieu; Ghika, Joseph-André; Burkhard, Pierre R; Van De Ville, Dimitri; Faivre, Nathan; Rognini, Giulio; ... (2021). Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network. Science translational medicine, 13(591) American Association for the Advancement of Science 10.1126/scitranslmed.abc8362

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Hallucinations in Parkinson's disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Krack, Paul

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1946-6234

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

13 Jul 2021 14:50

Last Modified:

13 Jul 2021 14:50

Publisher DOI:

10.1126/scitranslmed.abc8362

PubMed ID:

33910980

BORIS DOI:

10.48350/157481

URI:

https://boris.unibe.ch/id/eprint/157481

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