Bernasconi, Fosco; Blondiaux, Eva; Potheegadoo, Jevita; Stripeikyte, Giedre; Pagonabarraga, Javier; Bejr-Kasem, Helena; Bassolino, Michela; Akselrod, Michel; Martinez-Horta, Saul; Sampedro, Frederic; Hara, Masayuki; Horvath, Judit; Franza, Matteo; Konik, Stéphanie; Bereau, Matthieu; Ghika, Joseph-André; Burkhard, Pierre R; Van De Ville, Dimitri; Faivre, Nathan; Rognini, Giulio; ... (2021). Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network. Science translational medicine, 13(591) American Association for the Advancement of Science 10.1126/scitranslmed.abc8362
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Hallucinations in Parkinson's disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Krack, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1946-6234 |
Publisher: |
American Association for the Advancement of Science |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
13 Jul 2021 14:50 |
Last Modified: |
05 Dec 2022 15:52 |
Publisher DOI: |
10.1126/scitranslmed.abc8362 |
PubMed ID: |
33910980 |
BORIS DOI: |
10.48350/157481 |
URI: |
https://boris.unibe.ch/id/eprint/157481 |
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