Vouga, Manon; Favre, Guillaume; Martinez-Perez, Oscar; Pomar, Leo; Acebal, Laura Forcen; Abascal-Saiz, Alejandra; Hernandez, Maria Rosa Vila; Hcini, Najeh; Lambert, Véronique; Carles, Gabriel; Sichitiu, Joanna; Salomon, Laurent; Stirnemann, Julien; Ville, Yves; de Tejada, Begoña Martinez; Goncé, Anna; Hawkins-Villarreal, Ameth; Castillo, Karen; Solsona, Eduard Gratacos; Trigo, Lucas; ... (2021). Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scientific reports, 11(1), p. 13898. Springer Nature 10.1038/s41598-021-92357-y
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Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.
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