Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not All Subjects React the Same.

Zohdi, Hamoon; Scholkmann, Felix; Wolf, Ursula (2021). Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not All Subjects React the Same. In: Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology: Vol. 1269 (pp. 217-222). Springer 10.1007/978-3-030-48238-1_34

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BACKGROUND

In modern society, we are increasingly exposed to numerous sources of blue light, including screens (e.g., TVs, computers, laptops, smartphones, tablets) and light from fluorescent and LED lamps. Due to this wide range of applications, the effects of blue light exposure (BLE) on the human physiology need to be thoroughly studied.

AIM

To investigate the impact of long-term BLE on frontal and occipital human cerebral hemodynamics and oxygenation using functional near-infrared spectroscopy (fNIRS) neuroimaging.

MATERIALS AND METHODS

32 healthy right-handed subjects (20 females, 12 males; age: 23.8 ± 2.2 years) were exposed to blue LED light for 15 minutes. Before (baseline, 8 min) and after (recovery, 10 min) the BLE, subjects were in darkness. We measured the concentration changes of oxyhemoglobin ([O2Hb]) and deoxyhemoglobin ([HHb]) at the prefrontal cortex (PFC) and visual cortex (VC) by fNIRS during the experiment. Subjects were then classified into different groups based on their hemodynamic response pattern of [O2Hb] at the PFC and VC during BLE.

RESULTS

On the group level (32 subjects), we found an increase in [O2Hb] and a decrease in [HHb] at both cortices during BLE. Evoked changes of [O2Hb] were higher at the VC compared to the PFC. Eight different hemodynamic response patterns were detected in the subgroup analysis, while an increase of [O2Hb] in both cortices was the most common pattern (8 out of 32 cases, 25%) during BLE.

DISCUSSION AND CONCLUSION

Our study showed that the hemodynamic and oxygenation changes at the PFC and VC during BLE (i) were generally higher in the VC compared to the PFC, (ii) showed an intersubject variability with respect to their magnitudes and shapes, and (iii) can be classified into eight groups. We conclude that blue light affects humans differently. It is essential to consider this when assessing the impact of the BLE on society.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Zohdi, Hamoon; Scholkmann, Felix and Wolf, Ursula

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0065-2598

ISBN:

978-3-030-48238-1

Series:

Advances in Experimental Medicine and Biology

Publisher:

Springer

Language:

English

Submitter:

Svenja Hänni

Date Deposited:

19 Jul 2021 13:14

Last Modified:

20 Jul 2021 11:26

Publisher DOI:

10.1007/978-3-030-48238-1_34

PubMed ID:

33966220

Uncontrolled Keywords:

Blue light exposure Different hemodynamic response patterns Functional near-infrared spectroscopy Prefrontal cortex Visual cortex

BORIS DOI:

10.48350/157569

URI:

https://boris.unibe.ch/id/eprint/157569

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