Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient

Signorell, J; Hunziker, T; Martinelli, M; Koestner, S C; Mohacsi, P J (2010). Recurrent non-melanoma skin cancer: remission of field cancerization after conversion from calcineurin inhibitor- to proliferation signal inhibitor-based immunosuppression in a cardiac transplant recipient. Transplantation proceedings, 42(9), pp. 3871-5. New York, N.Y.: Elsevier 10.1016/j.transproceed.2010.07.090

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Non-melanoma skin cancers (NMSCs) are the most common malignancies after solid organ transplantation. Their incidence increases with time after transplantation. Calcineurin-inhibitors (CNIs) and azathioprine are known as skin neoplasia-initiating and -enhancing immunosuppressants. In contrast, increasing clinical experience suggests a relevant antiproliferative effect of mammalian target of rapamycin inhibitors, also named proliferation signal inhibitors (PSIs). We report the case of a cardiac allograft recipient with an impressive and consolidated reduction of recurrent NMSC, observed after conversion from CNI-therapy to a PSI-based protocol.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Signorell, Jan; Hunziker, Thomas; Martinelli, Michele; Köstner, Simon Charles and Mohacsi, Paul

ISSN:

0041-1345

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

06 Dec 2013 13:21

Publisher DOI:

10.1016/j.transproceed.2010.07.090

PubMed ID:

21094874

Web of Science ID:

000284969800097

URI:

https://boris.unibe.ch/id/eprint/1576 (FactScience: 203352)

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