SARS-CoV-2 Ig G among Healthcare Workers and the General Population.

Milani, Gregorio P; Bianchetti, Mario G; Togni, Giuseppe; Schoenenberger, Andreas W.; Muggli, Franco (2021). SARS-CoV-2 Ig G among Healthcare Workers and the General Population. Pathogens, 10(4) MDPI AG 10.3390/pathogens10040465

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It is assumed that healthcare workers are at the highest risk to be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, few data from healthcare workers who do not primarily take care of patients with SARS-CoV-2 infection support this assumption. We investigated the prevalence of immunoglobulin G (Ig G) against SARS-CoV-2 among healthcare workers who do not primarily take care of patients with SARS-CoV-2 infection and the general population in a well-defined geographical area. The first part of the study was conducted in May 2020 in Val Mesolcina (Southern Switzerland), a valley with ~8000 inhabitants. All healthcare workers were invited. All participants (n = 488) of the Swiss Longitudinal Cohort Study (SWICOS), a cohort representative of the general population, were also invited. Circulating Ig G against spike protein subunit 1 of SARS-CoV-2 were tested in each subject. Subjects with positive Ig G were tested again after 6 months. The condition of being a healthcare worker, rather than a part of the general population, was tested as a predictor of seroprevalence positivity by both simple and multiple (adjusted for age and sex) logistic regression. Eleven (2.6%) of the 423 SWICOS participants and 46 (16%) out of 289 healthcare workers were positive for antibodies against SARS-CoV-2. The seroprevalence OR was 7.01 (95% CI: 3.53-15.47) for healthcare workers as compared to SWICOS participants. After adjusting for age and gender, the seroprevalence OR was 5.13 (95% CI: 2.54-10.40). About three quarters of the subjects in the SWICOS (73%) and in healthcare (79%) group with a previous positive serology still presented positive Ig G against the SARS-CoV-2 after 6 months. The present seroprevalence data point out that the SARS-CoV-2 infection is seven times higher among healthcare workers than in the general population of Val Mesolcina. Efforts to effectively protect all the healthcare personnel are needed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic

UniBE Contributor:

Schoenenberger, Andreas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2076-0817

Publisher:

MDPI AG

Language:

English

Submitter:

Rebecca Rufer

Date Deposited:

22 Jul 2021 08:57

Last Modified:

22 Jul 2021 09:06

Publisher DOI:

10.3390/pathogens10040465

PubMed ID:

33921459

Uncontrolled Keywords:

COVID19 SARS-CoV-2 healthcare providers infection risk physicians

BORIS DOI:

10.48350/157608

URI:

https://boris.unibe.ch/id/eprint/157608

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